Multi-Peptide Micro-Infusion System 2.0
GHK-Cu + PDRN + NAD⁺ For Hooded Eyelids
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- Alex N.

"At 46, both my hooded eyelids were drooping as if I had lazy eyes. It killed my confidence especially in social situations. Been microneedling for 2 months and actually see a difference in how lifted my skin looks!"

- Alex N.

- Alex N.

- Tom B.

"My upper eyelids started drooping in my late 30s and by 44 it was affecting how people perceived me professionally. Six weeks with this and the sagging is visibly reduced. So happy with the results.

- Tom B.

- Tom B.

- Mark R.

"This micro-infusion system has helped lift my hooded eyelids more than anything else I've tried! My eyelids has been my insecurity for the past decade and I'm so glad I found something that actually works."

- Mark R.

- Mark R.

- James K.

"A few months of consistent use and I feel like a whole new man with how much more open my eyes look. So glad I didn't have to resort to surgery for my eyelids. Saved my confidence and my wallet!"

- James K.

- James K.

- David T.

"Felt like my hooded eyelids was such a turn off in my appearance when meeting women. Microneedling has helped a ton with lifting the skin around my eyes and I feel like I look more approachable now."

- David T.

- David T.

- Riley R.

"Thought I would have to live my ptosis or resort to surgery. But I'm very happy I gave this micro-infusion system a chance as I have noticed great results within a few weeks of using."

- Riley R.

- Riley R.

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- Miranda P.

"I used to hate how saggy my upper eye looked, its like I had a lazy eye. Microneedling completely reversed it and now my upper eye is snatched!"

- Miranda P.

- Miranda P.

- Annalise C.

"My hooded eyes made me look 10 years older. After 8 weeks, there's visible space between my lash line and crease again. I can't believe this worked without surgery."

- Annalise C.

- Annalise C.

- Fatima M.

"The fine lines around my upper eye have improved so much!! I was about to get an eyelid lift but this Micro-Infusion System works like a charm and has saved me so much money and pain!"

- Fatima M.

- Fatima M.

- Leena D.

"I'm 39 and my biggest insecurity is my droopy eye lids but I'm too scared to get surgical procedures done...This Micro-Infusion System has totally lifted my eyelids with just a few weeks of use!!"

- Leena D.

- Leena D.

- Sienna P.

"Love how my eyes look bigger and the skin around my upper & under eyes is more tight and snatched! Gotten so many compliments recently on how youthful I look!"

- Sienna P.

- Sienna P.

- Lana R.

"Can't stop raving about how much this Micro-Infusion System has transformed the skin around my upper eyes! A month of consistent use and my skin is so plump and firm."

- Lana R.

- Lana R.

Multi-Peptide Micro-Infusion System 2.0
GHK-Cu + PDRN + NAD⁺ For Hooded Eyelids

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Don't Mask Hooded Eyes, Restore Them (2x a Week)
⚡Naturally lift and tighten hooded eyelids
🧬Actives studied in wound-healing & longevity science
💉Painless micro-infusion—visible results in 4-8 weeks
🔬DNA-derived PDRN + 6 clinically-studied peptides

How It Works

This is the first micro-infusion system built for one job: the skin under your eyes. It pairs fast-acting de-puffing peptides, Acetyl Tetrapeptide-5 (AT-5) and our Chrysin Complex, with regenerative actives like GHK-Cu, PDRN, and NAD⁺. All drug-free. All in one formula.

How It Works
This is the first micro-infusion system built for one job: the thin, fold-prone skin of the upper eyelid. It pairs a regenerative duo—DNA-derived PDRN and the copper peptide GHK-Cu—with AT-2, a firming-and-tightening peptide, supported by NAD⁺ and palmitoyl peptides. All drug-free. All in one formula.

Why not fillers?
The upper eyelid is one of the most dangerous zones on the face for filler: paper-thin skin, the levator muscle that opens your eye sitting directly beneath, and zero margin for error. Even minor overfilling reads as puffiness, making lids look heavier instead of lifted. Migration under 10,000+ daily blinks can cause ptosis—a drooping lid that can block vision and require corrective surgery—and one wrong pass near the supraorbital vessels risks tissue damage or worse. Add the cost cycle ($700–$1,200 per session, every 6–12 months) and a dissolving process that can leave unevenness, and it's clear why most injectors won't touch this area. We built another way: nothing gets injected, nothing migrates, nothing swells.

What we do instead
Eye creams sit on the surface. Hooding forms deeper than that. Our 0.25mm channels carry a multi-active concentrate down to the layer where sagging, crepe, and lost elasticity actually develop—applied only to the fixed skin along the brow bone, never the moving lid—and those channels close within minutes.

Three mechanisms go to work at the same time, because a heavy lid is not one problem.

For crepey texture: GHK-Cu and PDRN handle the structural rebuild through fibroblast signaling, multi-collagen synthesis, and tissue repair. Thin, crinkled lid skin is where collagen loss shows first—and this duo works on exactly that layer.

For sagging and hooding: AT-2 supports the proteins your skin uses to assemble elastic fibers—fibulin-5 and LOXL1, the snap-back architecture that keeps a lid looking taut and lifted rather than heavy.

For fine lines: Palmitoyl peptides signal matrix renewal while NAD⁺ supports the cellular energy every repair process depends on—the surface creasing that firming alone won't touch.

Results build with each session instead of resetting every six months. No clinic visits. No vascular risk. No waking up with droopier eyes than before.

Just your upper eyes, renewed.

Real Results. Clinical Science.

See What's Possible

Reduces The Appearance of Hooded Eyes

Mark B.

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  • Helps reduce the look of eyelid heaviness linked to fluid retention
  • Supports improved upper-lid skin firmness with consistent use
  • Promotes a more open, less folded upper eyelid appearance*

Quote: "People kept asking if I was tired during meetings, even when I was wide awake. My heavy lids made me look checked out. After a few weeks, my eyes looked sharp again and people stopped assuming I wasn't paying attention."

Firmer, Less Saggy Upper Eyelids

Ahmed K.

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  • Helps improve the skin firmness that keeps hooded lids from folding further*
  • Reduces the appearance of sagging that deepens the hood over time
  • Promotes a smoother, more lifted-looking eyelid contour

Quote: "My hooded eyelids aged me 10+ years. I looked exhausted in every photo, every Zoom call. After a few weeks, my eyes looked alert and commanding again. I finally look like the man I actually am."

Reinforces Upper Eyelid Muscles

Samuel D.

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  • Helps reinforce the skin and tissue underneath hooded eyelids*
  • Improves the appearance of drooping caused by weakened periocular tissue
  • Encourages a more stable, lifted-looking lid position over time

Quote: "I've dealt with hooded lids for years and hated how much it affected my confidence. Didn't want to resort to surgery and I'm so glad I found this Micro-Infusion System. Saw amazing results after consistently using for about 2 months."

Visibly Lift Hooded Eyelids, Firm Crepey Skin, and Smooth Fine Lines

Your upper eyelids aren't just showing age. They're revealing years of collagen collapse, broken elastic fibers, and structural breakdown in the thinnest, most delicate skin on your face. When the eyelid loses its snap-back, skin folds over your lash line and hoods your eyes, texture turns thin and crepey, wrinkles deepen into creases—and your eyes look smaller, heavier, older. Most eye creams sit on the surface doing nothing.

Botanique Paris® Micro-Infusion System was built differently. Powered by DNA-derived PDRN, NAD⁺, and 6 clinically-studied peptides—led by the regenerative copper peptide GHK-Cu and the firming peptide AT-2—it delivers a multi-active concentrate to the layers where hooding, crepe, and fine lines actually form, with visible improvements in just 4-8 weeks.

Lifts Sagging Lids

Sagging lids lose their ability to "bounce back" because elastic fibers break down over time. Our system addresses this with Acetyl Tetrapeptide-2 (AT-2), Acetyl Tetrapeptide-5 (AT-5), and Adenosine. AT-2 supports fibulin-5 and LOXL1—the proteins your skin uses to assemble elastic fibers, the very scaffolding that gives eyelids their lift and resilience. AT-5 adds elastin support while helping manage the fluid heaviness that weighs lids down, and Adenosine energizes the tissue to relax surface tension. Together, they support the lid's natural look of lift and flexibility.

AT-2 PEPTIDE AT-5 PEPTIDE ADENOSINE

Reduces Visible Hooding

Hooded lids are driven by loss of dermal density and weakened, stressed skin. We target this with PDRN, Ectoin, and Beta-Glucan. PDRN (polynucleotides derived from DNA) supports the skin's natural renewal process and dermal density, while Ectoin—an extremolyte that protects cells under stress—helps defend fragile eyelid skin and reinforce its barrier. Beta-Glucan supports visible remodeling and calms micro-inflammation post-treatment. This combination creates visibly denser, more resilient lids.

PDRN ECTOIN BETA-GLUCAN

Smooths Crepey Texture

The delicate skin above the eye is the first to show age due to collagen loss. Our formula combats this with Copper Tripeptide-1 (GHK-Cu), Palmitoyl Tripeptide-38, and NAD⁺. By delivering these renewal signals directly to the dermis, we support the synthesis of Collagen I, III, and IV. NAD⁺ provides the essential cellular energy to fuel this repair process, smoothing the "crepey" texture and softening the depth of fine lines from the inside out.

GHK-CU PALMITOYL TRIPEPTIDE-38 NAD+

Visibly Firms & Tighten

Over time, eyelid skin can look loose and heavy due to gravity and structural fatigue. Our serum fights this with the matrikine duo Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7, Caffeine, and Sodium Heparin. The peptide duo signals your skin's own collagen-repair response, Caffeine boosts micro-circulation and tightens the appearance of the area, and Sodium Heparin—a water-binding glycosaminoglycan—supports a healthy repair environment. This blend lifts and defines the eyelid, combating the "drooping hood" look.

PALMITOYL TRIPEPTIDE-1 & -7 CAFFEINE SODIUM HEPARIN

Feel The Difference After Your First Sessions

Clinical research shows the right actives can start visibly lifting and firming hooded lids within weeks. With Botanique Paris® Micro-Infusion, users typically notice a more open eye appearance, reduced crepiness, and smoother upper-lid texture without the downtime, scarring, or cost of surgery. Your skin begins receiving targeted actives from session one, and your lids will look sharper and more defined with each use.

Why Eye Creams Never Worked For You

Traditional eye creams sit on the surface of your skin, never reaching the layers where sagging, crepey texture, and lost firmness become visible. Botanique Paris® Micro-Infusion works differently—precision 0.25mm delivery creates temporary micro-channels that carry a multi-active concentrate past the barrier of the thinnest skin on your face.

The result? PDRN and GHK-Cu firm crepey skin, AT-2 tightens and lifts the look of the hooded fold, and NAD⁺ with palmitoyl peptides smooths fine lines—all working where hooding actually starts, not sitting on top hoping to absorb.

Not an injectable. Not filler. Just targeted delivery that actually reaches the problem.

What Makes Botanique Paris®

The Ultimate Micro-Infusion System

Copper Tripeptide-1

Copper Tripeptide-1

The Matrix Reset Signal

  • Modulates 4,000+ genes; resets aged fibroblast expression toward youthful profiles.
  • Outperformed vitamin K in a 12-week eye-area clinical study for lines and skin density.

GHK-Cu is your anchor peptide for visible matrix renewal. It enhances TGF-β signaling, regulates MMPs, and activates antioxidant genes—making it uniquely suited for the thin, high-demand skin of the eyelid area.

Copper Tripeptide-1

Clinical Evidence

The Matrix Reset Signal

What it does: GHK-Cu resets aged fibroblast genetics toward youthful patterns. In periorbital skin specifically, it reduces wrinkles and increases skin density and thickness—making it the anchor active for crepey, thinning lid skin.

✓ Clinical study (N=41 women, 12 weeks) showed GHK-Cu eye cream reduced lines and wrinkles and increased skin density and thickness—outperforming both placebo and a vitamin K eye cream. pmc.ncbi.nlm.nih

✓ Gene-profiling research confirmed GHK modulates 4,000+ human genes (31.2% of genes changed ≥50%), upregulating collagen/antioxidant genes while downregulating pro-aging pathways. pmc.ncbi.nlm.nih

PDRN (Sodium DNA)

PDRN (Sodium DNA)

The Renewal Coordinator

  • DNA-derived polynucleotide studied in wound-healing; activates A2A receptors for repair signaling.
  • Doubled healing rates in clinical RCT (N=216); supports post-stamp comfort and visible renewal.

PDRN's adenosine-A2A-mediated pathways enhance controlled micro-wound response while buffering inflammation—ideal for comfort and visible renewal in repeated micro-infusion protocols.

PDRN (Sodium DNA)

Clinical Evidence

The Renewal Coordinator

What it does: PDRN activates adenosine A2A receptors to signal tissue repair, reduce inflammation, and stimulate fibroblast proliferation—ideal for post-stamp comfort and visible renewal on delicate lid skin.

✓ RCT (N=216, 8 weeks) demonstrated PDRN doubled complete healing rates (37.3% vs. 18.9% placebo) and cut median healing time from 49 to 30 days. pubmed.ncbi.nlm.nih

✓ Systematic review (34 studies) confirmed PDRN promotes tissue regeneration via A2A receptor activation with an excellent safety profile. pubmed.ncbi.nlm.nih

Acetyl Tetrapeptide-5

Acetyl Tetrapeptide-5

The De-Puffing Peptide

  • Helps reduce the excess fluid load that contributes to upper-eyelid heaviness and loss of definition.
  • Shown in vitro to support elastin and collagen markers while modulating fluid-regulating enzymes.
    ‎

Acetyl Tetrapeptide-5 helps limit capillary fluid leakage, reducing the downward fluid weight that adds to eyelid heaviness over time—supporting a firmer, more defined upper-lid appearance at the source.

Acetyl Tetrapeptide-5

Clinical Evidence

The De-Puffing Peptide

What it does: Acetyl Tetrapeptide-5 modulates ACE activity and vascular permeability to reduce excess fluid accumulation in periocular tissue—helping relieve the heaviness and downward load that contribute to a sagging, hooded look.

✓ In vitro research confirmed Acetyl Tetrapeptide-5 (in a peptide complex) modulates ACE activity and increased elastin and hydroxyproline production in skin cells. pubmed.ncbi.nlm.nih

✓ 2024 review of periorbital actives supports peptides among the evidence-backed ingredient classes for the eye area. pubmed.ncbi.nlm.nih

Palmitoyl Tripeptide-38

Palmitoyl Tripeptide-38

The Fine-Line Architect

  • Matrikine signal peptide that prompts synthesis of 6 major ECM constituents: Collagen I, III, IV, fibronectin, HA, laminin-5.
  • Matrikines are among the best-documented collagen-signaling routes in topical skincare.

This matrikine targets both superficial and deeper matrix layers. Its multi-collagen approach addresses crow's feet and upper-lid fine lines with systematic ECM renewal.

Palmitoyl Tripeptide-38

Clinical Evidence

The Fine-Line Architect

What it does: Stimulates 6 ECM components simultaneously (Collagen I, III, IV, fibronectin, HA, laminin-5)—addressing crow's feet and periorbital fine lines with comprehensive matrix support.

✓ 2024 pharmacology review details how matrikine peptides signal skin to rebuild extracellular matrix, with established roles in repair and anti-aging applications. pubmed.ncbi.nlm.nih

✓ 2024 review of periorbital actives includes collagen-signaling peptides among evidence-supported ingredients for eye-area fine lines. pubmed.ncbi.nlm.nih

NAD⁺

NAD⁺

The Cellular Power Plant

  • Central cofactor for ATP synthesis, DNA repair, and sirtuin activation.
  • Powers the machinery that executes GHK-Cu's genetic signals; declines ~50% across adult life.

NAD⁺ provides the cellular energy needed for collagen synthesis and repair. While GHK-Cu gives the instructions, NAD⁺ powers the machinery to actually execute them—like blueprints with a construction budget.

NAD⁺

Clinical Evidence

The Cellular Power Plant

What it does: NAD⁺ is the central energy cofactor for ATP synthesis, DNA repair, and sirtuin activation. While GHK-Cu provides the genetic instructions, NAD⁺ powers the cellular machinery to execute collagen synthesis—like blueprints with a construction budget.

✓ Human tissue research shows NAD⁺ in skin declines by at least 50% over the course of adult aging. pmc.ncbi.nlm.nih
✓ Molecular aging review confirmed NAD⁺ decline drives age-related cellular dysfunction, and that restoring NAD⁺-dependent processes is a major therapeutic target. pmc.ncbi.nlm.nih

Acetyl Tetrapeptide-2

Acetyl Tetrapeptide-2

The Lift Activator

  • Supports fibulin-5 and LOXL-1—the two proteins skin uses to assemble and anchor new elastic fibers.
  • Targets the elastic-fiber loss that research links directly to lid skin losing its snap and folding.

Acetyl Tetrapeptide-2 works on skin's elastic recoil system. As elastic fibers degrade, lid skin stretches, folds over itself, and hoods the eye—AT-2 supports the machinery that keeps skin springing back instead of draping down.

Acetyl Tetrapeptide-2

Clinical Evidence

The Lift Activator

What it does: Acetyl Tetrapeptide-2 is a firming peptide that supports fibulin-5 and LOXL-1, the proteins responsible for organizing and cross-linking new elastic fibers—the exact system that fails as upper-lid skin loses its recoil and begins to fold.

✓ Human skin research showed fibulin-5, a scaffold protein essential for elastic fibers, decreases and eventually disappears from the dermis with age—making it a key marker of skin aging. pubmed.ncbi.nlm.nih

✓ Experimental dermatology research identified LOXL as essential for elastic-fiber maintenance in adult skin and a validated target for increasing elastin content. pubmed.ncbi.nlm.nih

Adenosine

Adenosine

The Smoothing Signal

  • Boosts cellular energy (ATP precursor); clinically shown to reduce wrinkle depth.
  • Anti-inflammatory properties help calm puffiness and support skin recovery.

Adenosine works at the cellular level to energize tired skin while providing immediate smoothing benefits. Its anti-inflammatory action complements the de-puffing peptides to calm periorbital heaviness from multiple pathways.

Adenosine

Clinical Evidence

The Smoothing Signal

What it does: ATP precursor that energizes periorbital fibroblasts while providing immediate smoothing benefits. Its anti-inflammatory action calms puffiness from multiple pathways.

✓ RCT (N=126, 8 weeks) showed significant periorbital smoothness improvement from 3 weeks, measured by optical profilometry (Ra and Rz parameters). pubmed.ncbi.nlm.nih

✓ Clinical study (N=22, 10 weeks) demonstrated wrinkle-depth reduction and improved dermal density with enhanced penetration via microneedle delivery. pubmed.ncbi.nlm.nih

Caffeine

Caffeine

The Eye-Opener

  • Constricts excess microcirculation and supports fluid movement—reducing the look of morning lid puffiness.
  • Readily penetrates the skin barrier; one of the most-studied actives in cosmetic dermatology.

At 1%, caffeine tackles the fluid weight that makes hooded lids look heavier by mid-morning. Its vasoconstrictive and antioxidant actions pair with the de-puffing peptides to keep the upper-lid area looking lighter and more awake.matic ECM renewal.

Caffeine

Clinical Evidence

The Eye-Opener

What it does: Caffeine constricts small blood vessels and supports microcirculation in the periocular area, helping reduce the fluid accumulation that adds visual weight to hooded lids—while providing antioxidant protection.

✓ Dermatology review confirmed caffeine penetrates the skin barrier, constricts microvasculature, and provides antioxidant activity in topical application. pubmed.ncbi.nlm.nih

✓ 2024 review of periorbital actives lists caffeine among the evidence-backed ingredients for puffiness in the eye area. pubmed.ncbi.nlm.nih.gov

The Only Micro-Infusion System Your Upper-Eyelids Need

Eye creams sit on the surface. Eyelid surgery is a drastic leap. Botanique Paris® delivers clinically-studied actives directly where hooding, crepey skin, and fine lines originate—via painless 0.25mm precision stamping.

Beyond the 8 hero ingredients above, our serum includes Sodium Hyaluronate, Ectoin, and Beta-Glucan to amplify hydration, comfort, and barrier support.

Refresh Your Upper-Eyelids…

And Your Wallet Too!

Upper-eye filler appointments can cost upwards of ~$1,200 per session and leave you with bruising and swelling for a minimum of two weeks. Our 5-minute at-home treatment delivers the same dermal-delivery technology and visible lifting results, without the needles.

For 1/8th the price, here's what you get:

  • Visible lift on hooded lids in just weeks -- no bruising, no downtime
  • Clinically-backed ingredients that actually rebuild without repeat injections
  • 6 months of renewal for less than one filler appointment

Skip the expensive appointments and get sharper, less hooded eyes from home today.

Frequently Bought Together

CLINICIAN'S CHOICE

Erase Signs of Aging

In Just A Few Minutes Per Session

For Best Results: We recommend using the Micro-Infusion System 2 times
per week
, so that the serum's active ingredients can support visible firming and lifting while you rest!

STEP 1

Twist off the needle head and pour 0.5 mL of serum into the applicator using the dropper, then secure back on. Clean and dry the upper eyelid area. Only stamp on the brow bone and upper orbital rim—avoid the thin, mobile eyelid skin.

STEP 2

Stamp gently along the brow bone and upper orbital rim: 12–15 light stamps per side (25–30 total).Keep the device flat and use light, even pressure—no dragging.

STEP 3

Pour remaining serum onto clean fingertips. Massage onto untreated areas (forehead, temples, full face). For treated brow bone area: gently pat only (no rubbing). Let absorb—no rinsing for 8–12 hours (4 hours minimum). Avoid acids/retinoids for 24–48 hours. Expect visible improvement within 4–8 weeks.

Here's Why Men Love

Botanique Paris® Micro-Infusion System

It Targets All Three Upper-Eye Concerns

Unlike single-focus eye creams, our system works on the sagging, crepey texture, and fine lines behind hooding at once, with targeted actives like GHK-Cu, AT-2, and PDRN working in synergy.

Delivers Where Eye Creams Can't

Our precision micro-infusion technology delivers actives past the surface and into the layer where the hooded fold forms, so they reach the target instead of sitting on top.

Real Results In Just 4–8 Weeks

Feel the difference with visibly lifted, less folded lids and reduced fine lines within weeks. No more waiting months to see if an eye cream works.

Professional Results, Without The Surgery

Get visible lifting on hooded lids without bruising, swelling, or expensive appointments. Just 5 minutes, twice a week, from home.

Real Doses, Real Science

Every active is dosed at clinically-studied concentrations—PDRN, NAD⁺, Copper Peptide, and 5 targeted peptides working together, not just label decoration.

No Injections, No Dependency

Say goodbye to repeat injectable appointments and temporary fixes—our clean formula supports lasting renewal that works with your skin, not against it.

Visibly Lifted, Less Hooded Eyes in 365 Days-Or Your Money Back

Didn't see the lifting and firming you hoped for? You have 365 days to get a full refund—no questions asked.

Frequently Asked
Questions

YOU GOT QUESTIONS. WE GOT ANSWERS

What are the ingredients in the serum?

Our Upper-Eyelid Micro-Infusion Serum contains 8 clinically-studied hero actives plus supporting co-actives, each dosed at levels supported by published research—not token amounts for label appeal.

Core Regenerative Trio

  • Copper Tripeptide-1 (GHK-Cu): Your anchor peptide for visible matrix renewal and crepey-texture softening, especially effective when delivered via micro-infusion into thin eyelid skin.
  • PDRN (Sodium DNA): A DNA-derived polynucleotide that supports the skin's natural renewal process and post-stamp comfort in the delicate eyelid area.
  • NAD⁺ (Nicotinamide Adenine Dinucleotide): A cellular cofactor that supports skin energy, repair, and renewal at the mitochondrial level.

Lid-Lifting & Firming Peptides

  • Acetyl Tetrapeptide-2: The lift activator. Supports fibulin-5 and LOXL-1—the proteins skin uses to assemble new elastic fibers—helping firm the look of lids that fold and hood.
  • Acetyl Tetrapeptide-5: The de-puffing peptide that helps reduce the appearance of fluid-related heaviness and loss of lid definition.

Matrix Renewal Peptides

  • Palmitoyl Tripeptide-38: Signals multiple ECM constituents (collagens I/III/IV, laminin, fibronectin) for a smoother, firmer, more lifted-looking lid contour.
  • Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7: A classic signal-peptide duo that supports the look of firmness and elasticity across the brow-bone zone.

Smoothing & Circulation Support

  • Adenosine: Wrinkle-appearance softener that helps smooth crepey eyelid texture and fine lines.
  • Caffeine: Micro-circulation support that complements Acetyl Tetrapeptide-5 to reduce the look of morning lid puffiness and heaviness.
  • Chrysin + N-Hydroxysuccinimide: A supporting complex traditionally used to brighten the look of shadowed periorbital skin.

Barrier & Texture Support

  • Sodium Heparin (Heparan-Sulfate Analog): Replenishes a key ECM scaffold for barrier feel and fine-line appearance.
  • Biotin: Skin-conditioning agent that supports overall formula stability and skin feel.

Hydration & Comfort System

  • Sodium Hyaluronate (High Molecular Weight): Forms a moisture-locking barrier on the skin surface for lasting hydration.
  • Sodium Hyaluronate (Low Molecular Weight): Penetrates deeper to plump and hydrate from within, reducing crepey texture.
  • Glyceryl Glucoside: Supports natural moisture channels for enhanced hydration and skin resilience.
  • Betaine: Balances and soothes the skin while maintaining optimal hydration under stress.
  • Beta-Glucan: Accelerates visible remodeling and calms micro-inflammation post-treatment.
  • Ectoin: Extremophile-derived stress protector that shields skin from environmental and oxidative damage.

Vehicle & Delivery System

  • Aqua (Water): Purified water base.
  • Glycerin: Humectant that draws moisture to the skin for lasting hydration.
  • Propanediol: Lightweight, skin-friendly solvent that enhances active delivery.
  • Pentylene Glycol: Hydrating solvent with mild antimicrobial properties.
  • Steareth-20: Emulsifier that helps blend ingredients for a stable, even texture.
  • Polyquaternium-51: A skin-mimicking, breathable film former that helps actives stay in place while keeping skin comfortable.

Preservative & Stability System

  • Phenoxyethanol: Broad-spectrum preservative to keep the formula fresh and safe.
  • Ethylhexylglycerin: Preservative booster and skin-conditioning agent.
  • Chlorhexidine Digluconate: Preservative that supports formula safety and shelf stability.
  • Potassium Sorbate: Mild preservative that protects against microbial growth.
  • Citric Acid: pH adjuster for optimal formula stability and skin compatibility.
  • Sodium Citrate: Buffering agent that supports pH stability alongside citric acid.

No added fragrance. No silicones. Drug-free. Designed for micro-infusion and consistent at-home use.

How does it actually work?

Botanique Paris® combines precision micro-infusion technology with a multi-active serum built around PDRN, NAD⁺, copper peptides, Acetyl Tetrapeptide-2, and Acetyl Tetrapeptide-5.

The 0.25mm needles create temporary micro-channels that allow the serum to bypass the stratum corneum (the barrier that blocks most traditional topicals) and reach the dermal layer where hooding, crepey texture, and fine lines actually originate.

This improves absorption compared to surface application, supports collagen and elastin renewal and microcirculation pathways, and creates a healthier periorbital environment—all in a professional-grade, at-home routine.

How quickly will I see results?

Most users notice early improvements within 2–4 weeks of consistent
use. The first changes are typically reduced crepey texture, smoother
eyelid skin, and a more lifted, open-eye appearance.

More significant firming, wrinkle softening, and visible reduction in hooding
typically build over 6–12 weeks, depending on your starting point and
consistency. Skin renewal is gradual—progress photos every 4 weeks help
you see changes your eyes get used to daily.

Is it painful to use?

Most users describe the sensation as a mild tingling or light pressure—more like a firm facial massage than a "needle" feeling. Our 0.25mm precision needles are designed to stimulate the dermal layer without drawing blood or causing significant discomfort.

You may notice slight pinkness or warmth for 30–60 minutes after treatment—this is completely normal and indicates the micro-channels are active. If you have sensitive skin, start with lighter pressure and fewer stamps, then build up as your skin adjusts.

How often should I use it?

We recommend twice per week, with at least 2–3 rest days between sessions to allow your skin to complete its natural renewal cycle.

  • Week 1: Start with one session to test comfort and skin response.
  • Week 2+: Move to twice weekly (e.g., Monday and Thursday, or Tuesday and Saturday).

Consistency matters more than frequency. Twice weekly for 12 weeks will outperform sporadic daily use.

What's the needle depth?

Our Upper-Eye system uses precision 0.25mm needles only. This depth reaches the upper dermis where collagen remodeling and circulation signals are most active—without causing bleeding, bruising, or irritation to the delicate periorbital area.

Unlike the NLF (nasolabial fold) system, we do not recommend progressing to deeper needles around the eyes. The 0.25mm depth is optimized for this sensitive zone and delivers excellent results safely.

Is there any downtime?

Virtually none. You may experience mild pinkness or a slightly "flushed" appearance for 30–60 minutes post-treatment. This fades quickly and can be covered with mineral makeup if needed.

The micro-channels close within approximately 30–60 minutes. Most users perform their treatment in the evening and wake up with no visible evidence of the session—just brighter, more refreshed-looking eyes.

Where exactly should I stamp?

Stamp along the brow bone and upper orbital rim (the firm bony arc above your eye) in a line from inner corner to outer corner—stay 5–7mm above the lash line. For hooded lids and sagging skin, stamp along the brow bone and the firm area just above the crease.

Avoid the thin, mobile eyelid skin that moves when you blink and never stamp directly on the soft lid tissue. Only stamp on the brow bone and upper orbital rim where you feel firm support underneath.

Can I use it if I've had under-eye fillers?

Yes, but with timing considerations:

  • Before fillers: You can use the Micro-Infusion System right up until your filler appointment. Some users find that pre-treating the area improves skin quality and filler integration.
  • After fillers: Wait at least 2–4 weeks after injectable fillers before resuming micro-infusion in the treated area. This allows the filler to fully settle and reduces any risk of displacement.

If you're unsure, consult your injector. Many aesthetic practitioners now recommend micro-infusion between filler appointments to extend results and improve skin quality.

Is it safe for all skin types?

Yes. The Botanique Paris® Upper-Eyelid Micro-Infusion System is designed for all Fitzpatrick skin types (I–VI) and works across a range of upper-eyelid concerns—from early crepiness to established hooding and heaviness.

Our serum is fragrance-free, silicone-free, and formulated without harsh penetration enhancers that can trigger sensitivity. The barrier-support actives (Beta-Glucan, Ectoin) are specifically included to keep the delicate eye area calm between sessions.

Note: Apply only to the fixed skin along the brow bone—never the moving eyelid or lash line. Avoid use on broken, infected, or actively inflamed skin. If you have a history of keloid scarring or are currently using prescription retinoids, consult your dermatologist before starting.

Will Botanique Paris® Micro-Infusion Serum, with so many actives, overwhelm my skin or cause irritation?

Not at all. While the Botanique Paris® Upper-Eyelid Micro-Infusion Serum features multiple actives and co-actives (excluding water; the N-Hydroxysuccinimide + Chrysin Complex counted as one), they're selected and balanced for perfect synergy—not overload.

Most actives are gentle peptides, hydrators, and skin-calming agents, formulated at clinically-researched concentrations with the thin skin of the eyelid area in mind—supportive ingredients reinforce comfort, barrier strength, and tolerance. Plus, soothing co-actives like Ectoin and Beta-Glucan are included specifically to buffer and help prevent irritation.

For most users—even those with sensitivity—this means you benefit from deep, multi-layered renewal without risk of "doing too much." As always, start gradually and follow provided usage guidance, but this serum is formulated for consistent, visible results with minimal risk of irritation or overwhelm.

What should I avoid or be cautious about after applying Botanique Paris® Under-Eye Micro-Infusion Serum?

To ensure optimal results and protect your delicate under-eye area, please follow these post-application guidelines:

  • Do not touch or rub the treated area. Gentle tapping is all that's needed—the skin around the eyes is fragile, and rubbing can cause irritation or disrupt micro-channels.
  • Avoid applying other strong actives (such as retinol, exfoliating acids, or benzoyl peroxide) to the under-eye area for at least 48 hours. Combining too many powerful ingredients may lead to irritation.
  • Wait at least 4 hours before applying makeup, sunscreen, or other products on the treated skin—ideally overnight. This gives skin time to reseal and absorb all actives.
  • Do not use on broken, sunburned, or infected skin. Wait until the area is fully healed before resuming.
  • Do not wash the area or get it wet for at least 4 hours. Water can dilute the formula and disrupt the actives' penetration.
  • Steer clear of the lash line and eyelids. Keep product to the orbital bone to prevent accidental eye exposure.
  • Avoid waxing, threading, or in-office treatments (like chemical peels or lasers) on the eye contour for at least 7 days after use.
  • Minimize direct sun exposure immediately after application, and always use sunscreen the next morning—newly treated skin can be extra vulnerable.
  • Do not use more than recommended. Overuse may not improve results and may increase risk of redness, stinging, or sensitivity.
  • Discontinue if you notice persistent stinging, itching, swelling, or rash, and consult a healthcare provider if symptoms worsen.

Summary: Gentle handling, minimal product layering, sun protection, and patience with the healing process are key for the best, safest results. When in doubt, follow the included usage guide or reach out to our support team.

Can I use my own serums with the device?

We strongly recommend using only the Botanique Paris® serum with our micro-infusion system.

Here's why: not all serums are formulated for transdermal delivery. Many contain fragrances, essential oils, preservatives, or pH levels that can cause irritation or adverse reactions when delivered past the skin barrier—especially in the sensitive eye area.

Our serum is specifically engineered for micro-infusion—with a pH-balanced, irritant-free formula and actives dosed for dermal delivery, not surface application.

Is there a money-back guarantee?

Yes. We offer a 120-day money-back guarantee on all Micro-Infusion System purchases.

If you don't see the de-puffing and brightening results you hoped for after consistent use, simply contact us within 120 days for a full refund—no questions, no hassle. We only win when you see real results.

How is this different from derma-rolling?

Three key differences:

  1. Precision vs. drag: Derma-rollers drag across the skin at inconsistent angles, creating uneven micro-tears. Our stamping mechanism delivers perpendicular, controlled penetration at a consistent depth—less trauma, better channels. This matters even more in the delicate eye area.
  2. Integrated delivery: Rollers are separate from your serum. You roll, then apply, and hope absorption happens. Our system combines the micro-infusion device with a purpose-built serum, ensuring actives enter the channels while they're open.
  3. Targeted application: Rollers cover broad areas indiscriminately. Our precision head lets you target the under-eye crescent specifically—right where dark circles and puffiness live.

Think of it as the difference between a scattershot and a precision instrument.

Are the needle heads reusable?

Yes, with proper care. You can reuse a cartridge if you sanitize it after each session:

  1. Rinse the head under warm water to remove serum residue.
  2. Soak in 70 percent isopropyl alcohol for 10 minutes.
  3. Air-dry with needles facing up.

For optimal performance, we recommend replacing the head after approximately 5–8 uses. Needles gradually dull with use, and sharper needles create cleaner channels with less drag—especially important for the delicate eye area.

Pro tip: Mark each cartridge with a small dot after each use to track your count. If you ever notice bent needles, increased discomfort, or visible wear, replace immediately.

Is it easy to use?

Absolutely. The system is designed to be intuitive:

  1. Twist off the needle head, add 0.5mL of serum with the dropper, secure back on.
  2. Clean and dry the upper eyelid area.
  3. Stamp gently along the brow bone and upper orbital rim (12–15 stamps per side), staying on the firm bone above your crease.
  4. Pour any remaining serum onto fingertips and massage over the brow bone, upper eyelid (gently), and temple area.
  5. Let absorb—no rinsing for 8–12 hours.
How much of an area does one treatment cover?

Each 0.5mL session is calibrated specifically for bilateral upper eyelid treatment—both eyes, from inner corner to outer corner, along the brow bone and upper orbital rim.

If you're treating additional areas (crow's feet extending toward temples, forehead lines, etc.), you may need additional serum. Our multi-bottle bundles are designed for users who want to address multiple facial zones.

Who should use the Upper-Eye Micro-Infusion System?

The Upper Eyelid Micro-Infusion System is ideal for:

  • Adults struggling with hooded, sagging, or drooping upper eyelids that make eyes look heavy and tired
  • Those with crepey, wrinkled eyelid texture that creases makeup
  • Anyone noticing loss of lid definition and visible aging around the eyes
  • Those considering blepharoplasty who want to try a non-surgical option first
  • Post-blepharoplasty users who want to maintain results and prevent future sagging
  • Anyone who wants professional-grade delivery without surgical risk or scars
  • People who've tried countless eye creams without meaningful results

Not recommended for: Those with active eye infections, eczema, or open wounds in the treatment area; those currently on Accutane; those with a history of keloid scarring (consult your dermatologist first).

Will I lose my results if I stop using it?

After 3–4 months of consistent use, many users see meaningful firming, lifting, and improved skin quality that persists for some time after stopping.

However, skin biology is ongoing. If you completely stop any skincare routine, your eyelids will gradually return toward their baseline over months. Most users find that switching to a lighter maintenance schedule (once weekly, or a few times per month) helps preserve results without the full twice-weekly commitment.

I've tried every eye cream. Why would this be different?

Most eye creams fail for one reason: they never actually reach the dermis.

The stratum corneum (your skin's outer barrier) blocks most topically applied actives. You can have the best ingredients in the world, but if they're sitting on the surface, they're not reaching where hooding forms or where crepey texture originates.

Botanique Paris® solves the delivery problem:

  • 0.25mm micro-infusion creates temporary channels that guide actives directly to the dermal layer—bypassing the barrier that blocks ordinary eye creams.
  • Multi-pathway formulation addresses the look of sagging lids (Acetyl Tetrapeptide-2), crepey texture (GHK-Cu + PDRN), puffiness and heaviness (Acetyl Tetrapeptide-5 + Caffeine), and fine lines simultaneously—not just one mechanism.
  • Clinically-dosed actives at levels that match published research, not trace amounts for label decoration.

It's not magic. It's better delivery plus smarter formulation—built for people who are done hoping their next eye cream will finally work.

What makes Botanique Paris® different from other devices?

Most brands sell you a device and a generic serum separately—you become the formulator, hoping they work together.

Botanique Paris® was engineered as a complete system:

  • Delivery + formula, built together. The 0.25mm precision head is designed specifically for our serum's viscosity and active profile.
  • Multiple hero actives, not 1 token ingredient. PDRN, NAD⁺, GHK-Cu, Acetyl Tetrapeptide-2, and Acetyl Tetrapeptide-5—each targeting a different pathway in upper-eyelid aging.
  • Recovery built in. Beta-Glucan and Ectoin keep the delicate eye area comfortable enough to maintain a consistent twice-weekly routine.

One system. One serum. One job: deliver what your upper eyelids actually need, where they actually need it.